Immune Dysfunction and Immunotherapy in Heart Disease
Publisher: Blackwell Publishing 2007 | 308 Pages | ISBN: 9781405155687 | PDF | 15 MB
Publisher: Blackwell Publishing 2007 | 308 Pages | ISBN: 9781405155687 | PDF | 15 MB
Heart failure (HF) represents a major public health problem, affecting approximately 5 million patients in the United States and more than 550,000 new cases each year . Heart failure has an extremely complex multidimensional pathophysiology involving structural and functional cardiac disorders and increased neurohormonal activity, primarily mediated through the sympathetic nervous systemand the reninтАУangiotensinтАУaldosterone axis. Despite the diversity ofHF etiologies, a crucial process in the progression of most forms of HF is left ventricular remodeling.
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