Molecular Hematology by Drew Provan
Publisher: Wiley-Blackwell; 2 edition (February 18, 2005) | ISBN: 1405112557 | Pages: 344 | PDF | 26 MB
Publisher: Wiley-Blackwell; 2 edition (February 18, 2005) | ISBN: 1405112557 | Pages: 344 | PDF | 26 MB
The highly specialized functions of blood cells and their ready accessibility account in large part for the rapidly expanding knowledge of the molecular basis of hematologic diseases. In his foreword to this book, Max Perutz states that the day he spent trying to correlate amino acid substitutions in the globin molecule with the symptoms they may cause was "one of the most exciting days" in his scientific life. In Molecular Haematology, Provan and Gribben aim to show the ways in which molecular biology has profoundly influenced our understanding of blood diseases and the ways in which molecular techniques can be used in the diagnosis and treatment of these disorders.
The contributions cover the main fields of hematology, from inherited diseases to neoplasia. Several chapters deal with diagnostic techniques (molecular cytogenetics and the detection of minimal residual disease) and treatment (hematopoietic growth factors and gene therapy). Readers without a strong background in molecular biology will find detailed explanations, numerous diagrams, and an overview of recent advances in cancer-cell biology, with particular emphasis on leukemia and lymphoma.
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